C-peptide
About Test
The C-peptide test measures the level of C-peptide, a substance produced by the pancreas alongside insulin. C-peptide is a marker of insulin production, as it is released into the bloodstream in equal amounts to insulin. This test is used to assess pancreatic function and diagnose conditions related to insulin production.
In patients with Type 1 diabetes, the pancreas produces little to no insulin, resulting in low C-peptide levels. Conversely, in Type 2 diabetes, insulin production may be normal or high, often leading to normal or elevated C-peptide levels. The C-peptide test is also useful for evaluating insulinoma (a pancreatic tumour), and for monitoring patients undergoing treatment for diabetes or those with insulin resistance.
Regular monitoring of C-peptide levels helps healthcare providers evaluate pancreatic function, adjust treatment plans, and manage diabetes effectively, ensuring appropriate and personalised care for patients with hormonal and metabolic disorders.
Sample Requirements
Gold SST Tube
Stability
Serum: 4 hours at 15‑25 °C, 24 hours at 2‑8 °C,
30 days at ‑20 °C (± 5 °C)
Turnaround Time
4 hours
Assay Interferences
Recovery within ± 10 %
Bilirubin: ≤ 855 µmol/L or ≤ 50 mg/dL
Hemoglobin: ≤ 0.186 mmol/L or ≤ 300 mg/dL
Intralipid: ≤ 2000 mg/dL
Biotin: ≤ 246 nmol/L or ≤ 60 ng/mL
Rheumatoid Factors: ≤ 1200 IU/mL
Reference Range (pmol/L):
Fasting c-peptide
Absolute insulin deficiency: <80
Stimulated c-peptide
Absolute insulin deficiency: <200
Stimulated c-peptide in insulin-treated diabetic patients
Marked insulin deficiency and type1 DM: <600
Critical Value:
Not applicable