C-peptide

About Test

The C-peptide test measures the level of C-peptide, a substance produced by the pancreas alongside insulin. C-peptide is a marker of insulin production, as it is released into the bloodstream in equal amounts to insulin. This test is used to assess pancreatic function and diagnose conditions related to insulin production.

In patients with Type 1 diabetes, the pancreas produces little to no insulin, resulting in low C-peptide levels. Conversely, in Type 2 diabetes, insulin production may be normal or high, often leading to normal or elevated C-peptide levels. The C-peptide test is also useful for evaluating insulinoma (a pancreatic tumour), and for monitoring patients undergoing treatment for diabetes or those with insulin resistance.

Regular monitoring of C-peptide levels helps healthcare providers evaluate pancreatic function, adjust treatment plans, and manage diabetes effectively, ensuring appropriate and personalised care for patients with hormonal and metabolic disorders.


Sample Requirements

Gold SST Tube

Stability

Serum: 4 hours at 15‑25 °C, 24 hours at 2‑8 °C,
30 days at ‑20 °C (± 5 °C)

Turnaround Time

4 hours

Gold SST Tube

Assay Interferences

Recovery within ± 10 %

Bilirubin: ≤ 855 µmol/L or ≤ 50 mg/dL

Hemoglobin: ≤ 0.186 mmol/L or ≤ 300 mg/dL

Intralipid: ≤ 2000 mg/dL

Biotin: ≤ 246 nmol/L or ≤ 60 ng/mL

Rheumatoid Factors: ≤ 1200 IU/mL

Reference Range (pmol/L):

Fasting c-peptide

Absolute insulin deficiency: <80

Stimulated c-peptide

Absolute insulin deficiency: <200

Stimulated c-peptide in insulin-treated diabetic patients

Marked insulin deficiency and type1 DM: <600


Critical Value:

Not applicable