SHBG

About Test

The Sex Hormone-Binding Globulin (SHBG) test measures the level of SHBG, a protein produced by the liver that binds to sex hormones, including testosterone and oestrogen, in the blood. SHBG regulates the amount of free, biologically active sex hormones available to tissues and helps maintain hormonal balance.

This test is commonly used to evaluate conditions related to hormone imbalances, such as polycystic ovary syndrome (PCOS), thyroid disorders, and conditions involving abnormal levels of sex hormones. Elevated SHBG levels can be associated with conditions such as hyperthyroidism, liver disease, or oestrogen dominance. Conversely, low SHBG levels may indicate conditions like hypothyroidism, obesity, or androgen excess.

Monitoring SHBG levels helps healthcare providers assess hormonal health, diagnose endocrine disorders, and guide treatment strategies to balance hormone levels effectively. Regular testing is important for managing conditions related to hormonal imbalances and supporting overall health and well-being.

Sample Requirements

Gold SST Tube

Stability

Serum: 7 days 2-8°C

Turnaround Time

4 hours

Gold SST Tube

Assay Interferences

Interferences (Up to 5%)

Calcium: Above 15 mg/dL

Potassium: Above 7 mmol/L

Sodium: Above 180 mmol/L

Iron: Above 800 ug/dL

Zinc: Above 500 ug/dL

Magnesium: Above 4 mg/dL

Copper: Above 600 ug/dL

Bilirubin (conj): Above 15 mg/dL

Lipemia: Above 600 mg/dL

Haemolysis: Above 2 g/L

Reference Range:

0.40 - 1.00 Therapeutic / 1.00 - 2.00 Moderately Toxic / >2.00 Severely Toxic

Known factors:

Increased Lithium

  • Problem: Incorrect container or anticoagulant
    Caused by: Lithium Heparin Tube

Critical Value:

Not applicable