Thyroid peroxidase Antibody (anti-TPO)

About Test

The Thyroid Peroxidase Antibody (anti-TPO) test measures the level of antibodies against thyroid peroxidase, an enzyme produced by the thyroid gland that is crucial for the synthesis of thyroid hormones. The presence of these antibodies can indicate an autoimmune response where the body's immune system attacks thyroid tissue.

This test is commonly used to diagnose and monitor autoimmune thyroid disorders, such as Hashimoto's thyroiditis and Graves' disease. Elevated levels of anti-TPO antibodies are often associated with autoimmune thyroiditis, which can lead to hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid).

Monitoring anti-TPO antibody levels helps healthcare providers assess the presence and progression of autoimmune thyroid conditions, guide treatment strategies, and evaluate the effectiveness of therapies. Regular testing is important for managing autoimmune thyroid disorders and ensuring optimal thyroid function and overall well-being.


Sample Requirements

Gold SST Tube

Stability

Serum: Stable for 3 days at 2‑8 °C, 1 month at -20 °C

Turnaround Time

4 hours

Gold SST Tube

Assay Interferences

Recovery within ± 10 %

Bilirubin: < 1129 umol/L

Hemolysis: < 0.15 mmol/L

Lipemia: < 23.9 mmol/L

Biotin: < 40.9 nmol/L

Rheumatoid Factors: 450 IU/mL

Reference Range (IU/mL):

Negative: <25

Doubtful clinical significance: <35

Clear positive: 36 - 45


Critical Value:

Not applicable