Total Bilirubin
About Test
The Total Bilirubin assay measures the concentration of bilirubin, a yellowish pigment produced during the breakdown of red blood cells, in the blood. This test is essential for assessing liver function and diagnosing various liver and bile duct disorders. Bilirubin is formed when hemoglobin, the protein in red blood cells responsible for carrying oxygen, is broken down. Elevated total bilirubin levels may indicate conditions such as liver disease, bile duct obstruction, or hemolytic anemia, where red blood cells are destroyed at an accelerated rate. Jaundice, a yellowing of the skin and eyes, is a common symptom associated with high bilirubin levels. Conversely, low bilirubin levels are less common but could be associated with conditions such as malnutrition, severe liver disease, or certain medications' side effects. Doctors often include bilirubin testing as part of liver function panels to evaluate liver health comprehensively. This test provides valuable insights into a patient's liver function and helps guide treatment decisions to manage liver and bile duct disorders effectively.
Sample Requirements
Gold SST Tube
Stability
Serum: 3 days 2-8°C, Protect from light
Turnaround Time
4 hours
Assay Interferences
Interferences
Lipemia: Interference less than 10% 500mg/dL Intralipid
Hemolysis: Interference less than 10% 500mg/dL Haemolysate
Other: In very rare cases gammopathy, especially monoclonal IgM (Waldenström’s macroglobulinemia), may cause unreliable results.
Reference Range (µmol/L):
Neonate: 1.7 – 180.0 / Child: 3.0 – 17.0 / Adult: 3.0 – 22.0
Critical Value:
If above 205 umol/L